Register | Login

Asian Journal of Pediatric Research

  • About
    • About the Journal
    • Submissions & Author Guideline
    • Accepted Papers
    • Editorial Policy
    • Editorial Board Members
    • Reviewers
    • Printed Hard copy
    • Subscription
    • Membership
    • Publication Ethics and Malpractice Statement
    • Digital Archiving
    • Contact
  • Archives
  • Indexing
  • Publication Charge
  • Submission
  • Testimonials
  • Announcements
Advanced Search
  1. Home
  2. Archives
  3. 2022 - Volume 10 [Issue 3]
  4. Original Research Article

Author Guidelines


Submit Manuscript


Editorial Board Member


Membership


Subscription


A Study of Plasma Homocysteine Level in Children with Autism

  •   Shahenda Bdair Al-Beltagy
  •   Hesham Ahmed El-Serogy
  •   Sahar Abd ElAzim Abd Elaziz
  •   Tarek Mohammed Al-Gohary

Asian Journal of Pediatric Research, Volume 10, Issue 3, Page 31-37
DOI: 10.9734/ajpr/2022/v10i3199
Published: 9 November 2022

  • View Article
  • Download
  • Cite
  • References
  • Statistics
  • Share

Abstract


Background: Autism is a neurodevelopmental disorder that appears in early life. B6 and B12, and folate support homocysteine (Hcy) metabolism. Hence, any defect to them leads to Hcy accumulation in the body. Hcy, vitamins B12, B6 and folate are important in psychiatric disorders such dementia, schizophrenia, and autism. This study intended to compare the plasma Hcy levels in normal and autistic cases to find out whether there is difference between the levels of Hcy in plasma of autistic and normal children.

Methods: This case control study enrolled 60 children who were allocated in two groups 30 with autism and other 30 as controls. All patients were exposed to full history taking, physical examination, mental status examination, hearing test, routine lab investigations and specific lab investigations (serum folic acid, plasma vitamin B12 and Hcy level).

Results: Childhood Autism Rating Scale (CARS) level among autistic children was 49.400 ± 5.840. The mean plasma Hcy level was considerably higher in children with autism than controls (P value< 0. 01). The mean serum folic acid level and vit B12 level was significantly reduced in autistic cases than controls (P value< 0. 01). There was a statistically significant positive correlation between plasma Hcy level (µmol/L) and CARS level in children with autism (P value< 0. 01).

Conclusions:  Children with autism have increased levels of Hcy, and decreased levels of folic acid and vit B12. So, Hcy may be used as a clinical biomarker for early diagnosis and managing of autistic children.

Keywords:
  • Homocysteine
  • autism
  • CARS
  • folate
  • vitamin B12
  • Full Article - PDF
  • Review History

How to Cite

Al-Beltagy, S. B., El-Serogy, H. A., Elaziz, S. A. E. A., & Al-Gohary, T. M. (2022). A Study of Plasma Homocysteine Level in Children with Autism. Asian Journal of Pediatric Research, 10(3), 31–37. https://doi.org/10.9734/ajpr/2022/v10i3199
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

References

Shawky RM, El-baz F, Kamal TM, Elhossiny RM, Ahmed MA, El Nady GH. Study of genotype–phenotype correlation of methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in a sample of Egyptian autistic children. Egypt J Med Hum Genet. 2014;15:335-41.

Hertz-Picciotto I, Schmidt RJ, Krakowiak P. Understanding environmental contributions to autism: Causal concepts and the state of science. Autism Res. 2018;11:554-86.

Sala R, Amet L, Blagojevic-Stokic N, Shattock P, Whiteley P. Bridging the gap between physical health and autism spectrum disorder. Neuropsychiatr Dis Treat. 2020;16:1605-12.

Esse R, Barroso M, Tavares de Almeida I, Castro R. The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art. Int J Mol Sci. 2019;20:867.

Kaluzna-Czaplinska J, Michalska M, Rynkowski J. Homocysteine level in urine of autistic and healthy children. Acta Biochim Pol. 2011;58:31-4.

Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016;8:68.

Incekas Gassaloglu S, Baykara B, Avcil S, Demiral Y. [Validity and Reliability Analysis of Turkish Version of Childhood Autism Rating Scale]. Turk Psikiyatri Derg. 2016;27:266-74.

Yektas C, Alpay M, Tufan AE. Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls. Neuropsychiatr Dis Treat. 2019;15:2213-9.

Altun H, Kurutas EB, Sahin N, Gungor O, Findikli E. The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders. Clin Psychopharmacol Neurosci. 2018;16:383-90.

Józefczuk J, Kasprzycka W, Czarnecki R, Graczyk A, Józefczuk P, Magda K, et al. Homocysteine as a diagnostic and etiopathogenic factor in children with autism spectrum disorder. J Med Food. 2017;20:744-9.

Sun C, Zou M, Zhao D, Xia W, Wu L. Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial. Nutrients. 2016;8:337-41.

Han Y, Xi QQ, Dai W, Yang SH, Gao L, Su YY, et al. Abnormal transsulfuration metabolism and reduced antioxidant capacity in Chinese children with autism spectrum disorders. Int J Dev Neurosci. 2015;46:27-32.

Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, et al. Folic Acid and Autism: A Systematic Review of the Current State of Knowledge. Cells. 2021;10:1976-85.

Guo BQ, Li HB, Ding SB. Blood homocysteine levels in children with autism spectrum disorder: An updated systematic review and meta-analysis. Psychiatry Res. 2020;291:1132-38.

Erden S, Akbas Ileri B, Sadic Celikkol C, Nalbant K, Kilinc I, Yazar A. Serum B12, homocysteine, and anti-parietal cell antibody levels in children with autism. Int J Psychiatry Clin Pract. 2022;26:8-13.

Saha S, Saha T, Rajamma U, Sinha S, Mukhopadhyay K. Analysis of association between components of the folate metabolic pathway and autism spectrum disorder in eastern Indian subjects. Mol Biol Rep. 2022;49:1281-93.

Bala KA, Dogan M, Mutluer T, Kaba S, Aslan O, Balahoroglu R, et al. Plasma amino acid profile in autism spectrum disorder (ASD). Eur Rev Med Pharmacol Sci. 2016;20:923-9.

Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 2003;26:137-46.

Rai V. Association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with autism: evidence of genetic susceptibility. Metab Brain Dis. 2016;31:727-35.

Pasca SP, Nemes B, Vlase L, Gagyi CE, Dronca E, Miu AC, et al. High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life sciences. 2006;78:2244-8.

Fuentes-Albero M, Cauli O. Homocysteine Levels in Autism Spectrum Disorder: A Clinical Update. Endocr Metab Immune Disord Drug Targets. 2018;18:289-96.

Razi B, Imani D, Makoui MH, Rezaei R, Aslani S. Association between MTHFR gene polymorphism and susceptibility to autism spectrum disorders: systematic review and meta-analysis. Res Autism Spectr Disord. 2020;70:10147-53.

Shaik Mohammad N, Sai Shruti P, Bharathi V, Krishna Prasad C, Hussain T, Alrokayan SA, et al. Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders. Psychiatr Genet. 2016;26:281-6.

Frye RE, James SJ. Metabolic pathology of autism in relation to redox metabolism. Biomark Med. 2014;8:321-30.

Fulceri F, Morelli M, Santocchi E, Cena H, Del Bianco T, Narzisi A, et al. Gastrointestinal symptoms and behavioral problems in preschoolers with Autism Spectrum Disorder. Dig Liver Dis. 2016;48:248-54.

Xia RR. Effectiveness of nutritional supplements for reducing symptoms in autism-spectrum disorder: a case report. J Altern Complement Med. 2011;17:271-4.

Al-Farsi YM, Waly MI, Deth RC, Al-Sharbati MM, Al-Shafaee M, Al-Farsi O, et al. Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism. Nutrition. 2013;29:537-41.

Ali A, Waly MI, Al-Farsi YM, Essa MM, Al-Sharbati MM, Deth RC. Hyperhomocysteinemia among Omani autistic children: a case-control study. Acta Biochimica Polonica. 2011;58.

Hjiej H, Doyen C, Couprie C, Kaye K, Contejean Y. Substitutive and dietetic approaches in childhood autistic disorder: interests and limits. Encephale. 2008;34:496-503.

Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, et al. Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatr. 2011;11:1-30.

Ramaekers VT, Blau N, Sequeira JM, Nassogne MC, Quadros EV. Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits. Neuropediatrics. 2007;38:276-81.

  • Abstract View: 242 times
    PDF Download: 67 times

Download Statistics

Downloads

Download data is not yet available.
  • Linkedin
  • Twitter
  • Facebook
  • WhatsApp
  • Telegram


Copyright © 2010 - 2023 Asian Journal of Pediatric Research. All rights reserved.