Successfully Treated Case of Non-Typhoidal Salmonella Meningitis in an Otherwise Healthy 5 Months Old Infant: A Case Report

Main Article Content

Sana Hannan
Abdul Ahad Sohail


Acute bacterial meningitis in infants is a medical emergency requiring prompt diagnosis and early institution of empirical antibiotic therapy. Non-typhoidal salmonella (NTS) is a major cause of uncomplicated infectious diarrhoea worldwide; however NTS meningitis is extremely uncommon beyond the neonatal period with very few cases being reported in the literature and has been associated with increased mortality and morbidity with mortality rates of up to 40-70% reported in recent studies. NTS being a facultative intracellular organism does not respond to conventional antibiotic therapy and therefore failure and relapse rates are higher particularly with meningitis. We report a rare case of a five month old infant with non-typhoidal salmonella meningitis who was successfully treated with prolonged duration of antibiotic therapy.

Non-typhoidal salmonella, meningitis, infant

Article Details

How to Cite
Hannan, S., & Sohail, A. (2019). Successfully Treated Case of Non-Typhoidal Salmonella Meningitis in an Otherwise Healthy 5 Months Old Infant: A Case Report. Asian Journal of Pediatric Research, 2(3), 1-6.
Case Study


Anne RP, Vaidya PC, Ray P, Singhi PD. Salmonella typhimurium meningitis in an infant presenting with recurrent meningitis. The Indian Journal of Pediatrics. 2017; 1-3.

Adhikary R, Joshi S, Ramakrishnan M. Salmonella typhimurium meningitis in infancy. Indian Journal of Critical Care Medicine: Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine. 2013;17(6):392.

Wen SC, Best E, Nourse C. Non‐typhoidal Salmonella infections in children: Review of literature and recommendations for management. Journal of Paediatrics and Child Health. 2017;53(10):936-41.

Wu HM, Huang WY, Lee ML, Yang AD, Chaou KP, Hsieh LY. Clinical features, acute complications, and outcome of Salmonella meningitis in children under one year of age in Taiwan. BMC Infectious Diseases. 2011;11(1):30.

Keusch GT. Salmonellosis. In: Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, et al., editors. Harrison’s Principles of Internal Medicine. 14th Ed. New York: McGraw-Hill. 1998; 950-6.

Ploton MC, Gaschignard J, Lemaitre C, Cadennes A, Germanaud D, Poncelet G, Bidet P, Faye A, Basmaci R. Salmonella Typhimurium bacteraemia complicated by meningitis and brain abscess in a 3‐month‐old boy. Journal of paediatrics and child health. 2017;53(2):204-5.

Lee WS, Puthucheary SD, Omar A. Salmonella meningitis and its complications in infants. Journal of Paediatrics and Child Health. 1999;35(4): 379-82.

Price EH, de Louvois J, Workman MR. Antibiotics for Salmonella meningitis in children. Journal of Antimicrobial Chemotherapy. 2000;46(5):653-5.

Chiu CH, Ou JT. Persistence of Salmonella species in cerebrospinal fluid of patients with meningitis following ceftriaxone therapy. Clinical Infectious Diseases. 1999;28(5):1174-5.

Barrios P, Badía F, Misa V, Mota MI, Martinez A, Mariño H, Algorta G, Prego J, Pírez MC. A five-year experience with zoonotic Salmonella at a pediatric reference centre. Revista Chilena de Infectologia: Organo Oficial de la Sociedad Chilena de Infectologia. 2017;34(4):359-64.

Feasey NA, Dougan G, Kingsley RA, Heyderman RS, Gordon MA. Invasive non-typhoidal salmonella disease: An emerging and neglected tropical disease in Africa. The Lancet. 2012;379(9835):2489-99.

Khan MI, Ochiai RL, Von Seidlein L, Dong B, Bhattacharya SK, Agtini MD, Bhutta ZA, Do GC, Ali M, Kim DR, Favorov M. Non‐typhoidal Salmonella rates in febrile children at sites in five Asian countries. Tropical Medicine & International Health. 2010;15(8):960-3.

Totan M, Küçüködük Ş. Neonatal Salmonella typhimurium meningitis: Report of a case. Gazi Medical Journal. 2001; 12(3).

American Academy of Pediatrics. Salmonella infections. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2012 Report of the Committee on Infectious Diseases. Elk Grove Village: American Academy of Pediatrics. 2012; 635–40.