Concurrent Sickle Cell Anemia and Diabetes Mellitus with Ketosis in a Libyan Toddler: First National Report and Youngest Case Study

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Moftah Alhagamhmad
Alia Alhassony
Abdulhamid .
Aisha Elarwah
Shirin Alougly
Suliman Elbrgathy
Nuri Shembesh
Emhemed Mousa

Abstract

Sickle cell Anemia (SCA) is a common inherited haemoglobinopathy resulting from a single-point mutation on the β-globin subunit of hemoglobin. It is a chronic condition with multi-system involvement. Growth delay, osteopenia and hypogonadism are common endocrine dysfunctions with a lower frequency of impaired glucose tolerance. However, there is an association between SCA and diabetes mellitus (DM), though it is very rare. Certainly, there are only a few published reports worldwide outlined this uncommon combination. In this report, we will present the first Libyan case study of co-existence of the two diseases in a-16-month-old male toddler recording the youngest patient diagnosed with such a rare combination. The child, who was diagnosed earlier with SCA, brought with concerns of frequent changing nappies (polyuria) and excessive thirst (polydipsia) for 2 weeks that worsened recently. On admission, the toddler was distressed, lethargic and his lab parameters showed hyperglycemia, ketonuria, glycosuria and acidosis, a diagnosis of diabetic ketoacidosis (DKA) on the background of SCA therefore was made. Further observations are warranted to properly guide about the diagnosis and management of such rare cases.

Keywords:
Anemia, diabetes mellitus, ketosis, sickle cell, toddler

Article Details

How to Cite
Alhagamhmad, M., Alhassony, A., ., A., Elarwah, A., Alougly, S., Elbrgathy, S., Shembesh, N., & Mousa, E. (2020). Concurrent Sickle Cell Anemia and Diabetes Mellitus with Ketosis in a Libyan Toddler: First National Report and Youngest Case Study. Asian Journal of Pediatric Research, 3(4), 15-19. https://doi.org/10.9734/ajpr/2020/v3i430134
Section
Case Study