Main Article Content
Introduction: Langerhans cell histiocytosis is a systemic proliferative disease. It is a rare disease that can affects all tissues. Evolution can be spontaneously favorable. Multi-organ involvement may be life-threatening. We report the case of an toddler with bone lesion and issues.
Case Report: It was a 33-month-old infant with right shoulder pain. Clinically, she had a swelling in the front side of the right shoulder with a limited abduction. X-ray of the right shoulder showed osteolysis with an irregular boundary of the right humeral head. The blood work was normal. In view of the painful swelling of the right shoulder, a biopsy was performed. Histological examination confirmed the diagnosis of Langerhans histiocytosis. A conservative treatment was decided after a multidisciplinary consultation meeting. After six months, spontaneous improvement was noted.
Conclusion: Langerhans cell histiocytosis is a proliferative pathology that can affect one or more organs. The clinical presentation is polymorphic according to the affected organ. An extension assessment is fundamental in the management in order to determine the treatment.
Goubin AG, Donadieu J, Barkaoui. Descriptive epidemiology of childhood Langerhans cell histiocytosis in France. Pediatr Blood Cancer. 2008;51:71-5.
Lucaya J. Histiocytosis X. Am J Dis Child. 1971;121(4):289-95.
Vassallo R, Ryu JH, Colby TV, Hartman T, Limper AH. Pulmonary Langerhans cell histiocytosis. N Engl J Med. 2000;342: 1969-78.
Donadieu J, Heritier S. Histiocytose Langerhansienne de l’enfant. Presse Med. 2017;46(1):85-95.
Bollini G, Jouve JL, Launay F. Manifestations orthopédiques des histiocytoses Langerhansiennes. Arch Pediatr. 2008;15(5):526-8.
Satter EK, High WA. Langerhans cell histiocytosis: A review of the current recommendation of the histiocyte society. Pediatr Dermatol. 2008;25(8):291-5.
Histiocytosis syndromes in children. Writing Group of the Histiocyte Society. Lancet. 1987;1:208-9.
Nanduri VR, Pritchard J, Levitt G. Long term morbidity and health related quality of life after multi-system Langerhans cell histiocytosis. Eur J Cancer. 2006;42:2563-9.
Mc Lelland J, Broadbent V, Yeomans E, Malone M, Pritchard J. Langerhans cell histiocytosis: The case for conservative treatment. Arch Dis Child. 1990;65(3):301-3.
Meyer J, Harty P, Mahboubi S, Heyman S, Zimmermann R, Womer R, Dormans J, D’Angio G. Langerhans cell histiocytosis: Presentation and evolution of radiologic findings with clinical correlation. Radiographics. 1995;15:1135-1146.
Rivera-Luna R, Alter-Molchadsky N, Cardenos-Cardos R, Martinez-Guerra G. Pediatr Blood Cancer. 1996;26(5):334-43.