Severe Perinatal Asphyxia and Risk of Neonatal Jaundice at a Tertiary Hospital in Northern Nigeria

I. A. Imoudu; M. O. Yusuf; A. T. Aro; P. E. Akpabio; Z. M. Waziri

doi:10.9734/ajpr/2021/v5i330176

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Severe Perinatal Asphyxia and Risk of Neonatal Jaundice at a Tertiary Hospital in Northern Nigeria

I. A. Imoudu

M. O. Yusuf

A. T. Aro

P. E. Akpabio

Z. M. Waziri

Asian Journal of Pediatric Research, Page 17-22
DOI: 10.9734/ajpr/2021/v5i330176
Published: 23 March 2021

Abstract

Background: The risk factors of neonatal jaundice are largely known, yet there is little agreement on the association between it and perinatal asphyxia.

Aim: To investigate the association between severe perinatal asphyxia (SPA) and the risk of clinical jaundice (NNJ) among neonates managed at the Federal Medical Centre, Azare, Nigeria.

Methodology: Case control design was employed. Medical records of 315 babies managed at the special care baby unit from 1^st January, 2011 to 31^st December, 2018 were analysed. The exposure of interest was SPA and the outcome was jaundice. Logistic regression was applied to demonstrate the relationship between neonatal jaundice and SPA. Relative risk was provided as odds ratio and 95% confidence interval.

Results: Sixty-three cases and 252 controls were enrolled in the study. The mean age of the cases (4.39) and that of the controls (4.95 ) did not differ significantly (t= -0.52, P= 0.30). One hundred and fifty-six (61.9%) of the controls were males while 34 (54.0%) of the cases were females. For 59 (93.7%) of the cases treatment for jaundice was done with phototherapy and 1.6% required exchange blood transfusion. SPA significantly reduced the risk of developing NNJ (adjusted OR = 0.27, P-value ˂ 0.01).

Conclusion: We demonstrated a significantly reduced risk of developing neonatal jaundice with prior exposure to severe perinatal asphyxia. Prospective multicenter and community based studies correlated with serum bilirubin levels are recommended.

Keywords:

Severe perinatal asphyxia
neonatal jaundice
risk
phototherapy

How to Cite

Imoudu, I. A., Yusuf, M. O., Aro, A. T., Akpabio, P. E., & Waziri, Z. M. (2021). Severe Perinatal Asphyxia and Risk of Neonatal Jaundice at a Tertiary Hospital in Northern Nigeria. Asian Journal of Pediatric Research, 5(3), 17-22. https://doi.org/10.9734/ajpr/2021/v5i330176

References

Olusanya BO, Osibanjo FB, Slusher TM. Risk factors for severe neonatal hyperbilirubinaemia in low and middle- income countries: A systemic review and meta-analysis. PLoS ONE. 2015;10(2): e0117229. DOI: 10.1371/ journal. Pone. 0117229. Accessed 7 June 2020.

Patra C, Sarkar S, Dasgupta MK. Study of hepatic enzyme activity as a predictor of perinatal asphyxia and its severity and outcome. Indian J Health Sci Biomed Res. 2016;9:297-302.

Chhavi N, Zutshi K, Singh NK, Awasthi A, Goel A. Serum liver enzyme pattern in birth asphyxia associated liver injury. Pediatr Gastroenterol Hepatol Nutr. 2014; 17(3):162-9.

Choudhary M, Sharma D, Dabi D, Lamba M, Pandita A, Shastri S. Hepatic dysfunction in asphyxiated neonates: Prospective case-controlled study. Clin Med Insight Pediatr. 2015;9:1-6.

Kaplan M, Muraca M, Hammerman C, et al. Imbalance between production and conjugation of bilirubin: A fundamental concept in the mechanism of neonatal jaundice. Pediatrics. 2002; 110(4). Available:www.pediatrics.org/cgi/content/full/110/4/e47 Accessed 10 June 2020.

Ekwochi U, Osuorah CD, Ndu IK. Correlation between total serum bilirubin and clinic-laboratory parameters of babies admitted for neonatal jaundice in a resource- limited setting. Int J Clinicopathol Correl. 2018;2:21-6.

Gunaseelan S, Devadas S, Pai N. Correlation of transcutaneous bilirubin and serum bilirubin concentration in term and late preterm newborns. J Clin Neonatol. 2017;6:154-8.

Charan J, Biswas T. How to calculate sample size for different study designs in medical research. Indian J Psychol Med. 2013;35(2):121- 6.

Benaron DA, Bowen FW. Variation of initial serum bilirubin rise in newborn infants with type of illness. Lancet. 1991;338(8759): 78-81.

Zou L, Yuan H, Liu Q, Lu C, Wang L. Potential protective effects of bilirubin following the treatment of neonatal hypoxic- ischaemic encephalopathy with hypothermia therapy. Bioscience Reports 2019; 39 BSR20182332. Available:http://doi.org/10.1042/BSR20182332. Accessed 7 June 2020

Moyer VA, Abn C, Sneed S. Accuracy of clinical judgement in neonatal jaundice. Arch Pediatr Adolesc Med. 2000; 154(4):391-4.

Dani C, Poggi C, Fancelli C, Pratesi S. Changes in bilirubin in infants with hypoxic- ischaemic encephalopathy. Eur J Pediatr. 2018;177:1795-1801.

Noreen S, Farooq S, Kinza H, Mukharma M, Muhammad AR. Analysis of consequences of birth asphyxia in infants: A regional study in southern Punjab, Pakistan. Journal of the College of Physicians and Surgeons Pakistan. 2016;26(12):950- 3.

Sharma D, Choudhary M, Lamba M, Shastri S. Correlation of Apgar score with asphyxial hepatic injury and mortality in newborns: A prospective observational study from India. Clin Med Insights Pediatr. 2016;10:27-34.

Dennery PA, McDonagh AF, Spitz DR, Rodgers PA, Stevenson DK. Hyperbilirubinaemia results in reduced oxidative injury in neonatal Gunn rats exposed to hyperoxia. Free Radic Biol Med. 1995;19:395-404.

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