Selenoprotein-p as Biomarker of Selenium Status in Obese Children and Adolescents
Kholoud Gamal Mahmoud *
Pediatrics Department, Faculty of Medicine, Tanta University, Egypt.
Rasha Mohamed Gamal Elshafiey
Pediatrics Department, Faculty of Medicine, Tanta University, Egypt.
Radwa Mahmoud Elsharaby
Clinical Pathology Department, Faculty of Medicine, Tanta University, Egypt.
Amany Mahmoud Elbarky
Pediatrics Department, Faculty of Medicine, Tanta University, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Background: The child and adolescent obesity have become a major public health problem. Selenoprotien p1 (SEPP1) is widely acknowledged to be among the most delicate functional indicators of Se status and it plays a role in the metabolism of Se and in anti-oxidative defense. So, we aimed to assess Selenoprotein-p level in obese children and adolescents.
Methods: This cross-sectional comparative work included 60 children: 30 obese children and the control group consisted of 30 children who were healthy and matched in terms of gender and age. A comprehensive taking of history and clinical assessment with anthropometric measurements were conducted on all children and adolescents. Basic investigations and serum selenoprotien-p1 level were performed.
Results: Serum selenoprotien-p1 (SEPP1) levels were substantially decreased in obese children contrasted to controls.
Conclusions: Selenoprotien p1 levels were substantially decreased in obese children and adolescent. Selenoprotien p1 could be a sensitive functional biomarker of selenium status.
Keywords: Obesity, obese children, selenium status, selenoprotien p1