Macrophagic Activation Syndrome Revealing Tuberculosis: A Case Report

R. Majd *

Department of Paediatrics, Hôpital Militaire Mohamed V Rabat, Morocco.

A. Radi

Department of Paediatrics, Hôpital Militaire Mohamed V Rabat, Morocco.

A. Laarej

Department of Paediatrics, Hôpital Militaire Mohamed V Rabat, Morocco.

A. Hassani

Department of Paediatrics, Hôpital Militaire Mohamed V Rabat, Morocco.

R. Abilkassem

Department of Paediatrics, Hôpital Militaire Mohamed V Rabat, Morocco.

*Author to whom correspondence should be addressed.


Abstract

We present a case involving an immunocompetent infant diagnosed with miliary tuberculosis complicated by macrophage activation syndrome. Macrophage activation syndrome (MAS), also known as bone marrow hemophagocytosis, presents as a non-specific clinical condition characterized by fever and hepatosplenomegaly. A 22-month-old infant from a non- consanguineous marriage, the only child in the family, was admitted to a regional hospital due to prolonged fever lasting 15 days. The syndrome can manifest as a primary disorder (familial HLH) due to various genetic mutations or as a sporadic secondary disorder triggered by infections, autoimmune diseases, or malignant conditions. The early initiation of antibacillary treatment in AMS complicating tuberculosis without the use of immunosuppressive drugs provides better management and improves the vital prognosis.

Keywords: Hemophagocytosis, antibacillary treatment, immunosuppressive drugs, macrophage activation syndrome


How to Cite

Majd, R., A. Radi, A. Laarej, A. Hassani, and R. Abilkassem. 2024. “Macrophagic Activation Syndrome Revealing Tuberculosis: A Case Report”. Asian Journal of Pediatric Research 14 (6):1-4. https://doi.org/10.9734/ajpr/2024/v14i6349.

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References

Filipovich AH, Chandrakasan S. Pathogenèse de la lymphohistiocytose hémophagocytaire. Hematol Oncol Clin North Am. 2015;29:895-902. DOI:10.1016/j.hoc.2015.06.007

Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48:124-131.

Joshua Osowicki, MBBS,Shiqi Wang, MBBS,§ et al. Tuberculose Congénitale Compliquée Par LA Lymphohistiocytose Hémophagocytique Copyright © 2015 Wolters Kluwer Health

Ju-Hee Seo, MD, Jun Ah Lee, MD, Dong Ho Kim, MD, Joongbum Cho, MD*, Jung Sub Lim, MD, PhD Hémophagocytose associée à la tuberculose chez un adolescent diagnostiquée par réaction en chaîne de la polymérase Korean J Pediatr. 2016;59 (1):43-46

Dilber E, Erduran E, Kalyoncu M, Aynaci FM, Okten A, Ahmetoglu A. Hemophagocytic syndrome as an initial presentation of miliary tuberculosis without pulmonary findings. Scand J Infect Dis 2002;34:689-92.

Gonzalez F, Vincent F. Cohen Infection-related hemophagocytic syndrome: Aetiologies and management Réanimation (200 Réanimation. 2009;18:284—2909:18, 284—290.