https://journalajpr.com/index.php/AJPR/issue/feed Asian Journal of Pediatric Research 2020-10-20T02:13:09+00:00 Asian Journal of Pediatric Research contact@journalajpr.com Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Pediatric Research</strong>&nbsp;<strong>(ISSN: 2582-2950)</strong> aims to publish&nbsp;high-quality&nbsp;papers in all aspects of&nbsp;‘Pediatric Research’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> https://journalajpr.com/index.php/AJPR/article/view/30153 Bartter Syndrome in Children; A Cause of Severe Hypokalemic Metabolic Alkalosis: Clinical Case Report and Literature Review 2020-10-20T02:13:09+00:00 A. Radi M. Akhrif akhrif2510@gmail.com M. Kmari A. Ourrai A. Hassani R. Abilkassem A. Agadr <p>Bartter syndrome is an inherited renal tubular disorder caused by a defective salt reabsorption in the thick ascending limb of loop of Henle. It characterized by urinary loss of sodium, potassium, and chloride; hypokalemic metabolic alkalosis; normal blood pressure, high plasma levels of renin and aldosterone. There is phenotypical and genetic variability of Bartter syndrome since were identified five genes responsible for five different forms of Bartter syndrome. The objective of this work is to report a clinical case to study the pathophysiological, clinical, biological and therapeutic features of this syndrome.</p> <p><strong>Materials and Methods: </strong>We reported a case of 04-month-old male infant admitted for acute dehydration secondary to polyuro-polydipsia syndrome and vomiting. In clinical presentation the patient had a dysmorphic syndrome with triangular face, protruding ears and flattened nasal root. Laboratory tests revealed hypokalemia, hyponatremia, metabolic alkalosis and hypercalciuria. Treatment with indomethacin was started at 1 mg/kg per day with favorable outcome.</p> 2020-10-10T00:00:00+00:00 ##submission.copyrightStatement##