Open Access Case Study

Limb-Girdle Muscular Dystrophy Type 2C: Case Report

A. Radi, Ouajid el. Bakkali, M. Kmari, A. Ourrai, A. Hassani, R. Abilkassem, A. Agadr

Asian Journal of Pediatric Research, Page 1-5
DOI: 10.9734/ajpr/2020/v3i330127

Limb-Girdle muscular dystrophy (LGMD) is a group of inherited disorders that lead to muscle weakness and skeletal muscle wasting involving the muscles around the hips and shoulders. This can cause a gait disturbance, difficulty running or even a complete loss of the ability to walk. The appearance of the disorder, the course and the muscles affected are variable between the different subtypes of the disease. Typically, patients with type 2C Limb-Girdle dystrophy (LGMD2C) start having symptoms early in infancy and lose their ability to walk around the age of 12. Others have less symptomatology and have late expression in adulthood. This disorder can affect the heart muscle in some patients. They can also have osteoarticular and vertebral deformations. The prognosis depends on the muscles often affected by respiratory failure.LGMD2C is caused by a pathogenic mutation in the SGCG gene. We report the case of a 13-year-old child, with a notion of femoral fracture at the age of 5 years and first degree consanguinity in the parents, no similar case in the family, and who presents since 3 years difficulty walking Clinical examination: walking, positive sign of Gowers, scapula alta, enlarged calves. On the biological level: CPK 6380, LDH 482, PAL 219, ASAT 68, ALAT 103. The electromyogram shows a slowing of the motor conduction speed of the external popliteal sciatic nerve with a slight loss of amplitude. Muscle biopsy objective a discreet dystrophic formula with a total absence of expression of gamma sarcoglycans and proteins of the muscle membrane. Gamma glycanopathy is genetically confirmed by the mutation of the δ-SG gene. A cardiac ultrasound was without abnormality.

Open Access Case Study

Schizencephaly with Agenesis of the Corpus Callosum in the Neonatal Period: A Case Report

Ouajid Bakkali, A. Dibi, A. Barkat

Asian Journal of Pediatric Research, Page 6-10
DOI: 10.9734/ajpr/2020/v3i330128

Schizencephaly is a rare abnormality in supratentorial brain development, the etiopathogenesis of which is not yet clear. This disorder consists of the presence of a slit bordered with gray poly-microgyric substance, which extends from the subarachnoid space to the ventricles: the ventricle and the cortex communicate with each other. Here we report an infant with this condition; its clinical, radiological and prognostic aspects. This infant had unilateral open slit schizencephaly with agenesis of the corpus callosum.

Open Access Short Communication

Parenting: Types, Effects and Cultural Variation

S. M. Yasir Arafat, Hasina Akter, Md Aminul Islam, Md. Mohsin Ali Shah, Russell Kabir

Asian Journal of Pediatric Research, Page 32-36
DOI: 10.9734/ajpr/2020/v3i330130

Studies have been coming out exploring different aspects of parenting and how the child has been shaped by parenting. Parenting is the emotional tone between parent and child. It is usually conceptualized by two dimensions, namely demandingness and responsiveness. Based on these dimensions, parenting has been conceptualized in four types mentioned as authoritative, authoritarian, permissive, and neglectful. Parenting has immediate as well as enduring effects on a child’s behavioral, emotional, personal, and cognitive development. However, parenting is deeply influenced by the culture which decides the limits of behavior that to be controlled and praised. This narrative review was aimed to discuss the dimensions, types, effect of parenting style on the child’s development, and cultural variation of it.

Open Access Original Research Article

Elucidation of Food Security as a Determinant of Malnutrition and Stunting on Children under Five Years: A Case of Insiza District, Matabeleland South, Zimbabwe

Beauty Ncube, Greanious Alfred Mavondo, Gwendolin Kandawasvika, Judith Audrey Chamisa

Asian Journal of Pediatric Research, Page 11-31
DOI: 10.9734/ajpr/2020/v3i330129

Introduction: Malnutrition remains a childhood scourge in Sub Saharan Africa, Southern Africa, Zimbabwe and in the Insiza District, in particular. The district is rich in mineral (gold) deposits, vibrant agricultural (animal husbandry) and diverse ecosystems that has potential support self-sufficiency of its population. However, the cause to <5-year-old malnutrition and stunting remain to opaque requiring elucidation.

Materials and Methods: A mixed method approach, where both qualitative and quantitative research methods were used to elicit and describe in-depth people’s experiences on determinants of malnutrition and stunting in the Insiza District among the <5-year-olds. Statistical comparisons were performed by one-way analysis of variance (ANOVA), followed by Tukey-Kramer multiple comparison post hoc test using Graph Pad In Stat Software. Both probability and purposive sampling were used to triangulate and corroborate findings deriving meaning to explain the factors associated with wasting/ underweight.

Results: Children with birth weights ±2.4kG were predominant in the study sample (57%) when compared to those who were born with 2.5-3.0 kG or >3.1 kG birth weights [19 fold more]. Two meals per day were taken frequently (57%) a mong adults comparable with birth weight underweight frequencies and feeding habits of infants <5-year-olds (53%), showing food insecurity in Isiza District. Households that lived on < US$1.00/day formed relatively the most prominent majority (73%) when compared to those who lived on US$0.87-1.67/day (23%) or US$1.87-2.50 (2%) or US$2.53-3.33 (2%). Health-related expenses (18.3%), education expenses (25%) and staple food related expenses (56.7%) took the bulk of the income without meaningful effect on child malnutrition. Fathers were over represented as household income usage decision markers in households with malnourished and stunted <5-year-olds (43%) compared to mothers, the family or both parents. Poverty was present in 65% of the households which had malnourished and or stunted children. Malnourishment was from nutritional deficit and non-nutritional lack (25%) while 20% had malnutrition from other determinants other than food consumption score.

Conclusion: More than half (57%) children who developed malnutrition were underweight at birth and born in families with who had two meals a day (57%). Malnutrition was influenced negatively by marital status, household leadership, household income, size, religion, educations status and consumption scores.

Open Access Original Research Article

Characteristics and Causes of Neonatal Mortality in Hospitalized Cases at Benghazi Children's Hospital (2013-2014)

Ashraf Rajab, Suad F. Elnasfi, Amal Elfakhri, Raja Elfakhri, Hind K. Elgetaany, Abeer Eltigane, Sami A. Lawgaly

Asian Journal of Pediatric Research, Page 37-42
DOI: 10.9734/ajpr/2020/v3i330131

Background: Neonatal morbidity and mortality are major global public health challenges with approximately 3.1 million babies worldwide dying each year in the first month of life. The vast majority of neonatal death occurs in developing countries.                                     

Aims: This study was undertaken to assess the magnitude of neonatal mortality and identify the main causes and associated factors of neonatal mortality.              

Methodology: A retrospective study of 5791 neonates was conducted in Benghazi children hospital from 1st January 2013 up to December 2014.             

Results: During the two years of the study there were 5791 neonates admitted to neonatal unit of Benghazi hospital, out of them 389 died (6.7% of total neonatal admissions) accounting for 59.6% of the total Paediatric deaths within the same period, moreover approximately one neonate died every 48 hours throughout the study period. There was a slight predominance of male deaths 225 (57.5%) over females 164 (42.5%). The majority of neonates were Libyan 365 (94%), 212 of them were born in Benghazi, while the remaining 177 from other cities. Preterm neonate accounted for 35% (138) of deceased neonates. The most common causes were lung diseases of prematurity (29%), sepsis (25%), Congenital Heart Diseases (12.5%), post-operative intestinal obstruction (7%), multiple congenital anomalies (7%), intractable convulsions (6.5%).

Conclusion: This study indicated that neonatal mortality represented the highest portion of all deaths reported at Benghazi children hospital during the study period. Lung diseases of prematurity was found to be the top leading cause followed by sepsis then congenital heart diseases. Male showed marginal predominance over female in this study. More than one third of deceased neonates were preterm.