Open Access Case Report

Solitary Mastocytoma in Children: Case Report

M. Lakhrissi, F. Jabourik, A. Bentahila

Asian Journal of Pediatric Research, Page 1-3
DOI: 10.9734/ajpr/2021/v6i330194

Solitary mastocytoma is the most common form of mastocytosis in children. The main symptom is pruritus. The treatment is symptomatic and it’s based on Topical corticosteroids. The prognosis is good with possibility of spontaneous regression at adulthood. This case report is about a 7-month-old infant that presented with an erythromatous papular lesion on the left temple. The patient responded well to topical steroids and antihistamines.

Open Access Case Report

Aortopexy for Tracheomalacia Via Partial Sternotomy

Zafer Turkyilmaz, Ramazan Karabulut, Ebru Ergenekon, Gokcen Emmez, Berrin Isik, Ibrahim Hirfanoglu, Teymursah Muradi, Melda Tas, Aysegul Simsek, Kaan Sonmez

Asian Journal of Pediatric Research, Page 25-29
DOI: 10.9734/ajpr/2021/v6i330198

Tracheomalacia (TM) is a disease that causes the airway obstruction of the tracheal lumen as a result of the structural disorder of the tracheal cartilage. We present a 4-month-old patient who developed ventilator depended TM after repair of esophageal atresia with tracheoesophageal fistula. Aortopexy and intraoperative flexible bronchoscopy were first performed via partial sternotomy in Turkey for this patient.  He was weaned from ventilatory support and extubated at the first  and discharged at the 8th post-operative day. Partial sternotomy is performed in the supine position, thus  it allows for intraoperative flexible bronchoscopy permitting to check for the adequacy of the aortopexy.

Open Access Original Research Article

Can India Go in for Pre- School / Pre- Verbal Eye Screening Now with Red Reflex? - A Feasibility Study

Himika Gupta, Ravikant Singh, Sunila Sanjeev Ernam

Asian Journal of Pediatric Research, Page 4-10
DOI: 10.9734/ajpr/2021/v6i330195

Aims: To study the feasibility and challenges for early vision screening of the 0-6 yr preverbal/ preschool children in both urban and rural settings of India using the simple Red Reflex test.

Study Design:Operational research.

Place and Duration of Study: Four settings (two urban and two rural) were designed to target the 0-6year old children. Model I .Pre School (Urban slum Population), Model II. Health Centre                (Urban Hospital), Model III. Immunization OPD of Municipal Hospital (Rural hospital) Model IV. Anganwadi Centre (Rural Population) was designed and conducted July 2017 –Dec 2017 (6 months).

Methodology: All models were conducted as single day vision screening camps except Model III which was an opportunistic screening for a period of 3 months (July – Sept 2017). Vision screening was done using Red Reflex test and follow up was done for three months. Data was analyzed on MS Excel and expressed in proportions / percentages. 

Results: Maximum children (155) were screened in Model I. Out of the 301 total children screened 33 (10.96%) had abnormal Red Reflex test. The yield was maximum 6 (17.14%) in Model III. Urban health centre Model I was the most time efficient model(average 0.74 minutes/child). 

Conclusions: Single day screening of population based cohort is time efficient but opportunistic screening using universal immunization programme model had maximum yield.

Open Access Original Research Article

Referral Review of a SNCU in a District Hospital in Resource Limited Setting: A Retrospective Observational Study

Deepak Kumar, Sonika Gupta

Asian Journal of Pediatric Research, Page 11-16
DOI: 10.9734/ajpr/2021/v6i330196

Introduction: Special newborn care units (SNCUs) have been established in several district and subdivisional hospitals to meet the challenges of high neonatal mortality. With single digit target of infant mortality in 2030, we need to review the functioning of these SNCUs in order to strengthen them to reach the target. So this study was undertaken with primary objective to study mortality and referral pattern.

Methods: This retrospective observational study was conducted in district hospital Udhampur by analysing case records from SNCU admissions over three years from 2017-2019

Results: There were total of 341, 352 and 414 admissions in 2017, 2018 and 2019 respectively with a cumulative sex ratio of 702/405(male/female) over these 3 years. Referral rate was 31.31%, 31.31% and 30.19% for 2017, 2018 and 2019 respectively, whereas mortality rate was 2.05%, 1.93% and 2.41% for these 3 years respectively. Respiratory distress syndrome (RDS), sepsis and birth asphyxia were the major causes for referrals.

Conclusion: With stagnant, non decreasing referral rates over 3 years, and ventilatory support as a major cause of referrals, a lot needs to be improved as far as respiratory support at SNCU level is concerned.

Open Access Original Research Article

Neuroimmune and Acute Psychotic Disorders had an Overlapping Immune-Signature in Adolescents and Young Adults; A Case Series

Jose Irazuzta, Nicolas Chiriboga Salazar

Asian Journal of Pediatric Research, Page 17-24
DOI: 10.9734/ajpr/2021/v6i330197

A misguided auto-reactive injury is responsible for diverse types of central nervous system (CNS) conditions. We suspect that, in some of these conditions, the adaptive immune system have a common cellular immune pathogenesis, driven predominantly by T cells, despite variability on the phenotypical clinical presentation.

Aim: the main goal of this study is to characterize a portion of the adaptive immune response (AIR) on patients presenting with clinical symptoms compatible with monophasic acute neuroimmune disorders (NID) including Psychotic Disorders (PD).

Methodology: flow cytometry with deep immunophenotyping of T effector (Teff) and T regulatory (Treg) cells was performed on peripheral blood obtained during the acute clinical phase and compared it to the one from an age-matched cohort group [Co).

Results: our preliminary findings point toward the presence of common “immunosignature” in individuals affected by NID or PD.  We also found a shared dysregulation of immune related neurogenes in NID and PD that were not present in normal cohorts.

Conclusions: this preliminary report gives some insights into the underlying shared pathobiology. If we can improve our capacity for early accurate diagnosis and meaningful disease monitoring of pathogenic T cell subsets, we will both expedite disease detection and may serve as a guide the administration of effective immunotherapeutic agents.