Open Access Case Report

Kawasaki Disease can Improve Autism: A Case Report and Literature Review

Xianpeng Yan, Yang Feng, Zhilong Mu, Fuyong Jiao

Asian Journal of Pediatric Research, Page 26-31
DOI: 10.9734/ajpr/2022/v10i2193

In this paper, we report a case of autism in a child who was cured of Kawasaki disease and the condition of autism was significantly improved. Kawasaki disease (KD), also known as cutaneous mucosal lymph node syndrome, was first reported by Japanese doctor Tomaku Kawasaki in 1967. In recent years, domestic and foreign studies believe that the pathogenesis of KD is significantly related to infection, genetic susceptibility and immune response, and its pathogenesis and treatment still need to be further studied. The occurrence of autism may be based on genetic predisposition and triggered by environmental factors during the critical period of immune establishment at the age of 1-3 years, which causes immune-mediated inflammation, changes the permeability of gastrointestinal tract and blood-brain barrier, and leads to chronic inflammation in the central nervous system, thereby affecting neurogenesis, migration and synaptic construction.

Open Access Case Study

Supraventricular Tachycardia (SVT) in Newborn Leading to a Hydrops Fetalis Syndrome: Case Report

S. Babour, M. Sellouti, A. Ayad, S. Saghir, R. Abilkassem, A. Agadr

Asian Journal of Pediatric Research, Page 32-36
DOI: 10.9734/ajpr/2022/v10i2194

Hydrops fetalis is defined by the accumulation of fluids in the serous membranes (pleurisy, ascites, pericarditis...), it is a rare condition; its etiologies are divided into immunological and non-immunological. Supraventricular tachycardia remains a known cause, non-immunological, but difficult to manage.

In this article we report the case of a newborn with hydrops fetalis secondary to supraventricular tachycardia, which failed to be treated.

The clinical, paraclinical, etiological diagnosis and finally the treatment were discussed.

Open Access Original Research Article

Assessment of Quantitative Serum SARS-CoV-2-IgM Antibodies in Febrile Children and It`s Relation to Radiological Findings in Tanta University Hospital

Dina Amin Adel Zahra, Ahmed Mohamed Abdelrazek, Maaly Mohammed Mabrouk, Mohamed Basiony Hamza

Asian Journal of Pediatric Research, Page 7-14
DOI: 10.9734/ajpr/2022/v10i2191

Background: Serological testing is urgently required since COVID-19 is the pandemic that is spreading the fastest in recent times, Although RT-PCR is an effective and specific method for diagnosing acute patients, serological tools are urgently required for examining antibody responses and evaluating both individual and prospective herd immunity. The aim of this study was divided into primary objectives were to assess serum IgM antibodies for SARS-Cov-2 in febrile children attending ER in Tanta University Hospital and secondary objectives were to assess computed tomography (CT) findings in febrile SARS-Cov-2 IgM antibody-positive individuals.

Methods: This cross-section study was carried out on sixty children presented by fever with any respiratory symptom as cough and dyspnea and fever with non-respiratory and cutaneous symptoms. The patients were divided into three equal groups: group 1: included healthy children, group 2: included febrile children with respiratory symptoms as cough and dyspnea and group3: included febrile children with fever alone or with non-respiratory symptoms as Gastrointestinal symptoms as vomiting and diarrhea, cutaneous manifestations as rash, and CNS manifestations.

Results: IgM were significantly higher in group II compared to other groups, significantly higher in group III compared to group I (P value <0.001).CO-RADS 2,4 and 5 were significantly higher in group II compared to other groups, CO-RADS 3 was insignificantly different between groups II and III. Patients with positive CXR at time of presentation were significantly higher in group II compared to other groups. (P value 0.005).

Conclusions: In children with COVID-19, Serum IgM to SARS-COV-2 was significantly higher in febrile children in Tanta University during the period from March 2021 to February 2022. According to CT findings, CO-RADS 2,4 and 5 were significantly higher in febrile patients with positive SARS-Cov-2 serum Igm Ab.

Open Access Original Research Article

Pattern of Neonatal Mortality at a Special Care Baby Unit in Rivers State, Nigeria

Boma Awoala West, Uchenna Onubogu, Adaku Arthur

Asian Journal of Pediatric Research, Page 15-25
DOI: 10.9734/ajpr/2022/v10i2192

Background: Neonatal mortality rate is an important indicator which does not only reflect the overall health of a child and well-being but also assesses the social and economic development of a country.

Aim: The study was carried out to determine the pattern and factors associated with neonatal mortality.

Methods and Materials: It was a retrospective study carried out in the Special care Baby Unit of the Rivers State University Teaching Hospital from January 2016 to December 2020.

Results: Of 2,944 neonatal admissions, 358 died giving a mortality of 12.2% with male preponderance (M:F ratio of 1.5:1). Majority of the neonates who died were admitted within the first 24 hours of life 289(80.7%) and were delivered via Caesarean section 195(54.4%). Most deaths occurred in the first 7 days of life 189(52.8%). The commonest cause of mortality was neonatal sepsis 183 (51.1%) followed by perinatal asphyxia 178(49.7%) and prematurity 176(49.2%). Most mortalities occurred between 4.00pm and 7.59 am 218(61.0%) outside regular work hours. The lowest annual mortality was recorded in the year 2020 (6.36%) while the highest was in the year 2018 (19.27%). There was significant mortality within 24hours of admission among neonates < 1.5 kg as well as those with sepsis, anaemia and neonatal jaundice.

Conclusion: The mortality rate of neonates in the Rivers State University Teaching Hospital was high, 12.2% with neonatal sepsis, perinatal asphyxia and prematurity being the commonest causes which are largely preventable. There is therefore need to improve obstetric and newborn care to improve neonatal outcome.

Open Access Review Article

Outpatient Therapeutic Programme for Malnourished Children

Yousef M. Alflah

Asian Journal of Pediatric Research, Page 1-6
DOI: 10.9734/ajpr/2022/v10i2190

Outpatient therapeutic programme (OTP) is one of the approaches of community-based management of acute malnutrition (CMAM), which includes community engagement and mobilization for outpatient management of uncomplicated severe acute malnutrition (SAM) children 6–59 months with good appetite, by providing them by home-based treatment as Ready-to-use Therapeutic Food (RUTF) and routine medical treatment. Around 85-90% of children with SAM are successfully treated at home in OTP, by attending regular intervals until they recover. OTP is currently used to achieve rapid recovery from SAM, it provides services of SAM management closer to the community at primary health care centers, where uncomplicated SAM children receive different amount of RUTF as Plumpy'Nut sachets according to their body weight.