Open Access Letter to the Editor

Open Access Case Study

Rare Cause of Neonatal Hypovolemic Shock: A Case Report

M. El. Hammoumi, H. Aguenaou, A. Barkat

Asian Journal of Pediatric Research, Page 9-13
DOI: 10.9734/ajpr/2021/v5i230168

The intracranial haemorrhage (ICH) of the term new-born is a rare pathology; the prevalence is estimated at 2% of live births. The clinical manifestations are variable and not specific. The causes of ICH are multiple and often intricate, the main pathophysiological mechanisms are deregulations of cerebral flow, obstruction of the vessels or intravascular coagulation or a direct injury from trauma. We report the case of a new-born at 30 hours of life admitted to our service (Neonatal resuscitation service and intensive care at Children's Hospital Rabat) for the management of respiratory distress on hypovolemic shock following which the clinical and biological examination was in favor of severe hemophilia A with factor VIII at 0.80%.

Open Access Short Research Article

COVID-19 in Children a Descriptive Study at the Security Forces Hospital (SFH)-AL Riyadh-Saudi Arabia

Elsharif A. Bazie, Abdulkarim Alanazi, Wejdan Hamed Abdullah Alshammari, Fahad Mishal Alharbi, Faisal Ahmed Alghamdi

Asian Journal of Pediatric Research, Page 21-27
DOI: 10.9734/ajpr/2021/v5i230171

Coronaviruses (CoV) are RNA respiratory viruses that present with a wide range of symptomatology which range from common cold to severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). In December 2019 a new strain was discovered in China named Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), named “COVID-19” by World Health Organization (WHO).

Objective: To study the prevalence and clinical presentation of COVID-19 among children attended pediatrics emergency department.

Result: from 1st March to 30th of June 2020. During the study period, a total of 223 patients with age between 16 days and 12 years were diagnosed as positive COVID-19. Male were 52%. Fever was found in 39.9%, cough in 14.3%, and diarrhea in 3.6%.

Conclusion: our study gives a clue to the clinical presentation of COVID-19 in pediatric populations.

Open Access Original Research Article

Clinical and Paraclinical Aspects of Febrile Convulsions in Children at the Ziguinchor Peace Hospital: Documentary Study

Lamine Thiam, Adama Coundoul, Isabelle Jokébé Coly, Ndiogou Seck, Djibril Boiro, Aliou Abdoulaye Ndongo, Idrissa Basse, François Niokhor Diouf, Moustapha Ndiaye, Amadou Lamine Fall, Ousmane Ndiaye

Asian Journal of Pediatric Research, Page 1-8
DOI: 10.9734/ajpr/2021/v5i230167

Introduction: Febrile seizures are seizures associated with fever in children. They represent a frequent reason for consultation in pediatric emergencies. Febrile convulsions are often qualified as benign pathologies but they are a source of concern, explaining the number of tolls imposed on these children. The aim of the study was to report the practice to a hospital in Senegal.

Materials and Methods: This is a retrospective study of children's records, from January 1, 2015 to January 31, 2020. Were included, patients aged less than or equal to 5 years, hospitalized in the pediatric department of the Ziguinchor Peace Hospital, for a febrile convulsion. Newborns and children with psychomotor development abnormalities were excluded. We have studied the clinical and etiological data.

Results: We collected 85 (51 boys, 34 girls) cases of febrile convulsions, ie a hospital frequency of 10,6%. The mean age of the patients was 23,6 months, peaking in infants 12 to 18 months. The mean temperature was 38,8° C and the seizure was tonic-clonic in 64,7%. We noted 57 cases of simple febrile convulsions (67,1%) and 28 cases of complicated febrile convulsions (32,9%). The etiology of fever was dominated by otorhinolaryngologic infections (42,4%); malaria (18,8%) and bronchopulmonary infections (08,2%). The average length of hospital stay was 02,8 days. We deplored two deaths (02,4%).

Conclusion: Febrile convulsions are common in children under 5 years old. They are secondary to respiratory tract infections and malaria.

Open Access Original Research Article

Study of Platelet Parameters with Different Isolated Organism in Neonatal Bacterial Sepsis

Rajiv Kumar Prasad, Amita Uday Surana, Chetan Chovatiya, Radhika Iyer, Nidhi Modi

Asian Journal of Pediatric Research, Page 14-20
DOI: 10.9734/ajpr/2021/v5i230170

Background: Thrombocytopenia is a common hematological abnormality observed in neonatal sepsis and considered as early, nonspecific marker of sepsis. The studies related to organism specific platelet response are few.

Objective: To assess the prevalence of thrombocytopenia and to study changes in various platelet parameters in relation to different isolated organism.

Methods: A prospective observational study involving neonates with 1st episode of culture positive sepsis was done over a period of 18 months. The platelet parameters studied were incidence, degree, duration of thrombocytopenia; mean platelet volume and platelet nadir among neonate with specific organism isolated.

Results: Out of 114 culture positive sepsis 31% Klebsiella, 30% Pseudomonas, 13% Citrobacter, 18% CONS, 4% Staphylococcus Aureus (S Aureus) and 3% had Acinetobacter sepsis. Overall prevalence of thrombocytopenia was 88%, of which klebsiella and S. Aureus sepsis observed 100% prevalence of thrombocytopenia followed by 88% pseudomonas, 80% coagulase negative staphylococci (CONS), 75% Acinetobacter and 66% Citrobacter sepsis. The proportion of severe degree of thrombocytopenia (18% Vs 4%), higher MPV (61% Vs 54%) and longer duration of thrombocytopenia (3.63 ± 0.49 Vs 2.95 ± 0.52) was observed more with Gram negative sepsis than with Gram positive sepsis and statistically significant difference in platelet nadir was observed with Gram negative sepsis. Severe degree of thrombocytopenia was seen in 50% neonates with Acinetobacter and 23% with Klebsiella sepsis. Acinetobacter, Klebsiella and Pseudomonas sepsis had higher mean MPV value, longer duration of thrombocytopenia and lowest platelet nadir.  The platelet parameters were less affected with Gram positive organism.

Conclusion: Thrombocytopenia is a frequent occurrence in neonates with sepsis especially with Gram negative organism. Sepsis with Acinetobacter, Klebsiella & Pseudomonas organism was associated with prolonged duration, higher MPV and lower platelet count as compared to                    other isolated organisms.