Open Access Original Research Article
Background: TORCH infection has a role in aplastic anemia (AA). Fetal hemoglobin may be high in certain acquired hematological conditions such as aplastic anemia. We conducted this study to evaluate the correlation between certain congenital infections and severity of aplastic anemia and to study fetal Hb as a follow up marker during treatment of aplastic anemia. The aim of study was to correlation between certain congenital infection and severity of aplastic anemia and to study of hemoglobin F (HbF) as a follow up marker during treatment of aplastic anemia.
Methods: Our prospective study was conducted on 20 children aged up to 18 years diagnosed with aplastic anemia following either bone marrow aspiration or biopsy that proves bone marrow hypocellularity with absence infiltrative BM disease or inherited BM disease recruited from Pediatric Hematology-Oncology Unit of Tanta University Hospital. Patients were classified according to level of HbF in to high HbF group and normal HbF group.
Results: TORCH infections were detected in certain numbers of patients . HbF decreased in high HbF group after treatment. There was significant increase in CBC parameters in high HbF group than normal HbF group after treatment. There was insignificant decrease in mortality in high HbF group than normal HbF group. Mild to moderate cases were significantly higher with TORCH IgM +ve cases
Conclusions: Acquired AA is associated with TORCH infection. In treated cases of AA, improvement of hematological parameters is associated with high HbF and from these results, it can be used as a prognostic marker to monitor the successful response of these cases to the used line of treatment.
Open Access Review Article
Background: Sickle cell disease is an inherited disorder of hemoglobin. It poses a public health problem in Senegal and mainly affects children and adolescents. Infections are the main cause of morbidity and mortality in children with sickle cell disease. The objective of our work was to assess infections associated with major sickle cell syndromes at the Ziguinchor Peace Hospital (ZPH).
Methods: This was a retrospective study, from October 1, 2015 to October 31, 2020. Included were sickle cell patients homozygous SS and heterozygous SC, hospitalized with fever ≥ 39°C, in whom an infectious assessment was performed. Excluded from the study were patients whose complete blood count, C-Reactive Protein, and rapid diagnostic test for malaria were not performed.
Results: During the study period, we collected 66 patient files (43 boys and 23 girls). The mean age was 7.6 years [8 months – 21 years]. The population consisted of SS sickle cell disease patients in 98.5% of cases. The average body temperature was 39.6°C [39 – 40.5°C]. The clinical picture on admission was predominantly vaso-occlusive crisis and anemia. The positivity of the bacteriological examinations was 2 cases for the blood culture, 3 cases for the urine culture. The infections were dominated by bronchopneumonia (31.8%); ear, nose and throat infections (31.8%) and osteoarthritis (15.2%). Four children presented with severe malaria and the immediate course was favorable for all patients.
Conclusion: otorhinolaryngological infections; Bronchopulmonary and osteoarticular diseases are frequent in children with sickle cell disease at the Ziguinchor peace hospital. we recommend support for the microbiology unit and systematic sampling in febrile sickle cell patients.