Long-Term Evolution of Patients with the Wolcott Rallison Syndrome: Case Series of 4 Patients and Review of Literatures
Najlae El Hafidi *
Pediatric Endocrinology Diabetology and Neurology Department, Rabat Children's Hospital, Mohamed V University in Rabat, Morocco.
Zineb Imane
Pediatric Endocrinology Diabetology and Neurology Department, Rabat Children's Hospital, Mohamed V University in Rabat, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Wolcott-Rallison syndrome is a rare autosomal recessive disorder characterized by neonatal diabetes in consanguineous families. associated with liver dysfunction, epiphyseal dysplasia, and. growth retardation. It is caused by mutations in the gene encoding eukaryotic translation initiation factor 2α kinase 3 (EIF2AK3).
We report a long-term evolution of 4 patients with Wolcott Rallison syndrome.
Keywords: Neonatal Diabetes, Wolcott-Rallison, long-term evolution