Progress of Animal Experimental Research on the Effect of Stem Cells on Coronary Artery Lesion in Kawasaki Disease
Zhilong Mu
Shaanxi Kawasaki Disease Diagnosis and Treatment Center, China.
Na Gao
Shaanxi Kawasaki Disease Diagnosis and Treatment Center, China.
Ting Dai
The Nursing Profession, Grade 2019, Xi’an Peihua University, Xi’an, China.
Xiaoyan Huang
Children's Hospital, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China and Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People’s Hospital, Xi’an, 710068, China.
Cuixiang Xu
Children's Hospital, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China and The Nursing Profession, Grade 2019, Xi’an Peihua University, Xi’an, China.
Xianpeng Yan
Shaanxi Kawasaki Disease Diagnosis and Treatment Center, China.
Hua Guo
Children's Hospital, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China and The Nursing Profession, Grade 2019, Xi’an Peihua University, Xi’an, China.
Fuyong Jiao *
Shaanxi Kawasaki Disease Diagnosis and Treatment Center, China.
*Author to whom correspondence should be addressed.
Abstract
Kawasaki disease (KD) is an acute, febrile, erupting, self-limited autoimmune disease with systemic vasculitis as the main lesion. It is more common in children under 5 years old, and the main lesions associate the coronary arteries. With the increasing incidence, it has become the first cause of acquired heart disease in children. There are many basic and clinical studies on Kawasaki disease at home and abroad, but there are few animal experimental studies on the treatment of coronary artery injury with stem cells. Therefore, it is of great value to select scientific experimental animal models for Kawasaki disease research to simulate the human characteristics of Kawasaki disease. Through the establishment and in-depth study of animal models of Kawasaki disease, it is helpful to better understand the pathophysiology, cytokines and molecular pathways related to disease advancement of Kawasaki disease. At the same time, it will augment the way for the development of new and effective diagnosis and treatment of Kawasaki disease. Therefore, based on the study of coronary artery lesion animal model of Kawasaki disease with stem cells, this article mainly discusses the research and new progress of Kawasaki disease animal models, so as to provide a good theoretical basis for clinical and animal experimental research. And make a review on this issue.
Keywords: Stem cells, kawasaki disease, coronary artery lesion, animal model, research, progress