Transgenerational Effects of Maternal Health
Imomoemi Nwinam Thompson *
NNPC Medical Services Limited, Port Harcourt, Nigeria.
Adetomi Bademosi
Department of Community Medicine, Faculty of Clinical Sciences, College of Medical Science, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Rivers State, Nigeria.
Golda Lugesi Ezeh
Department of Epidemiology, School of Public Health, University of Port Harcourt, Rivers State, Nigeria.
Sandra Ujunwa Ekesiobi
Department of Medical Laboratory Science, Niger Delta University, Bayelsa State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
This study highlights the profound impact of maternal health on offspring well-being through transgenerational effects, extending beyond direct genetic inheritance. It emphasizes epigenetic modifications, intrauterine environment, and maternal lifestyle factors, influencing fetal programming and health trajectories across generations. Understanding these mechanisms is crucial for developing targeted interventions to prevent intergenerational disease transmission and promote lifelong health. The seminar explores these complexities, examining mechanisms, implications for offspring health, and the role of environmental and socioeconomic factors. Current research underscores the importance of maternal health in shaping offspring outcomes, revealing associations with chronic diseases, neurodevelopmental disorders, and metabolic disorders. Epidemiological evidence supports these findings, emphasizing the need for interventions addressing health disparities and promoting health equity. Future research priorities include elucidating underlying mechanisms, integrating multi-omics approaches, and addressing societal and environmental determinants. Early intervention strategies, preventive measures, and policy recommendations are vital for mitigating adverse effects and improving maternal and offspring health outcomes, thereby breaking the cycle of intergenerational disease transmission and promoting health equity across generations.
Keywords: Epigenetics, health equity, maternal health, offspring health, transgenerational effects