Unusual Coexistence of Castleman's Disease and Pityriasis Lichenoides in a Child
Narjess Er-rachdy *
Department of Dermatology-Venereology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Ouissal Essadeq
Department of Dermatology-Venereology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Taha Aaboudech
Department of Anatomopathology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Kaoutar Znati
Department of Anatomopathology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Laila Benzekri
Department of Dermatology-Venereology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Nadia Ismaili
Department of Dermatology-Venereology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Castleman disease is a rare lymphoproliferative disorder, particularly in children. Its association with pityriasis lichenoides has not been previously reported. This report presents a 5-year-old girl born to consanguineous parents, who developed recurrent necrotic and bullous skin lesions diagnosed as chronic pityriasis lichenoides (CD8+). One year later, she developed bilateral cervical lymphadenopathy, and imaging revealed multiple necrotic nodes. A lymph node biopsy confirmed hyaline-vascular Castleman disease. This case suggests a potential immunological link between chronic pityriasis lichenoides and Castleman disease. The patient is scheduled for surgical excision of the lymph node mass and will undergo continued dermatologic follow-up. This is the first pediatric case reporting this rare coexistence, highlighting the need for systemic evaluation in chronic dermatoses with lymphadenopathy.
Keywords: Castleman disease, pityriasis lichenoides, CD8 , hyaline-vascular, child, lymphadenopathy