Anhidrotic Ectodermal Dysplasia: Report of Two Cases
Narjess Er-rachdy *
Department of Dermatology-Venereology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Ouissal Essadeq
Department of Dermatology-Venereology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Laila Benzekri
Department of Dermatology-Venereology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Nadia Ismaili
Department of Dermatology-Venereology, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Background: Anhidrotic ectodermal dysplasia (AED), also referred to as hypohidrotic ectodermal dysplasia, is a rare genetic condition characterized by a triad of hypotrichosis, hypodontia, and hypohidrosis.
Case Report: This article reports two illustrative cases: an adolescent and a child, both presenting with classic AED manifestations.
Discussion: We describe the clinical and histological features, provide insights into the diagnostic process, and discuss recent advances in the understanding and management of AED.
Conclusion: AED is a rare genetic disorder that requires early diagnosis, regular follow-up, and genetic counseling. New therapies offer promising outcomes.
Keywords: Anhidrotic ectodermal dysplasia, EDA mutation, hypohidrosis, dental anomalies, prenatal therapy, recombinant EDA-A1, genetic counseling