Exploring the Frequency and Indications of Alternative Blood Transfusion Strategies in Children with ABO and Rh Blood Types: A Systematic Review
Jacques Forwah Ndeh *
Department of Hematology and Blood Transfusion Sciences, Faculty of Clinical Sciences, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.
Edeani Bobby David
Department of Radiation Oncology, University of Nigeria Teaching Hospital, Ituku- Ozalla, Enugu, State Nigeria.
Edung Emem Samuel
Emergency Department, Basildon and Thurrock University Hospital London NHS Trust, United Kingdom.
Arinze Joseph Edochie
Department of Public Health, Queen Elizabeth Hospital Newcastle-UHB NHS Trust, United Kingdom.
Onajiyovwi M.Collins
Department of ENT, Nnamdi Azikwe University Teaching Hospital Nnewi, Anambra State, Nigeria.
Enomen Ekata
Department of General Practices, Askern Medical Centre, Doncaster, United Kingdom.
Uchenna Livinus Akuka
Department of Care of Elderly, Queen Elizabeth Hospital, Queen Elizabeth Avenue, Sheriff Hill, Gateshead, Tyne and Wear, NE96SX, England, United Kingdom.
Okoye Chukwuebuka Daniel
Department of Paedistrics, Asaba Specialist Hospital, Asaba, Delta State, Nigeria.
Okoli Ijeoma Chinasa
Department of Internal Medicine, Metropolitan Family Hospital, Ibadan, Oyo State, Nigeria.
Emefuru Juliet Adaku
Department of Internal Medicine, Lagos State Health Service Commission, Lagos State, Nigeria.
Tagbo Chinenye Peace
Department of Public, University of Nigeria Teaching Hospital Enugu State, Nigeria.
Tamarapiriye Powei Ojujoh
Department of medical Unit, NNPC Medical Services Ltd Benin City, Edo State, Nigeria.
Oluwatofunmi Olarewaju
Department of Family Medicine, Duchess International Hospital Ikeja Lagos State, Nigeria.
Ramatu Umar Ibrahim
Department of Family Medicine, Maitama District Hospital Abuja, Nigeria/ Kubwa General Hospital Abuja, Nigeria.
Ekere Chinedu Romanus
Department of Pediatrics mum’s, Care Hospital Lusaka, Zambia.
Ademola Samuel Adeyemi
Department of Internal Medicine, University of Ilorin, Kwara State, Nigeria.
Joy Heart Avong
Department of Paediatrics, Lifeline Children Hospital, Surulene Lagos, Lagos, Lagos State, Nigeria.
Olaosebikan Oluwaseun Dorcas
Department of Paediatrics, Kwara State Teaching Hospital, Ilorin, Kwara State, Nigeria.
Vivian Somtoochukwu Ibezim
Emergency Department, Royal Infirmary of Edinburgh, Scotland, United Kingdom.
Emekwue Chukwudi Alex
Department of Internal Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria.
Kingsley Akaba Onoride
Department of Hematology and Blood Transfusion Medicine, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.
Ofor Joshua Obase-Otumoyi
Department of Public Health, National Open University, Lagos State, Nigeria.
Idiege Idiege Omang
Department of Surgery, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.
Ofonime Benjamin Essien
Department of Hematology and Blood Transfusion Medicine, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.
Immaculate Ihuoma Ekeagba
Worcaccce Union Group Integrated Healthcare Sciences, Technological development and Training and Innovative Research Foundation (Wugihsttairf), P.O Box 45 Bamenda, North West Region, Cameroon.
Abeshi Sylvester Etenikang
Department of Obstetrics and Gyneacology, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background: Blood transfusions are crucial in pediatric care, particularly for children with hematological disorders. Understanding the impact of ABO and Rh blood types on transfusion outcomes is essential for optimizing patient care.
Objectives: This systematic review explores the frequency and indications of alternative blood transfusion (ABT) strategies in children with different ABO and Rh blood types, aiming to improve transfusion safety and efficacy.
Methodology: A comprehensive search was conducted across ten major databases, yielding 300 articles. After applying strict inclusion and exclusion criteria, 250 studies were included. The studies were assessed for quality, and data were extracted and synthesized.
Results: The review found that ABT strategies, such as restrictive transfusion thresholds and tranexamic acid, reduced transfusion requirements and improved clinical outcomes in children. ABO and Rh blood type frequencies varied significantly among study populations, suggesting these factors in transfusion decisions. Personalized transfusion approaches tailored to individual children's blood types and clinical needs are necessary.
Conclusion: This systematic review provides robust evidence on ABT strategies in children with different ABO and Rh blood types. The findings support personalized transfusion approaches that consider a child's unique blood type and clinical requirements, potentially leading to. The review's insights will inform clinical practice and guide future research in pediatric transfusion medicine, enhancing the quality of care for children requiring blood transfusions.
Keywords: Frequency/indication, ABO/Rh, transfusion, medicine outcomes, children