Open Access Case Study

Pycnodysostose Associated with Stridor: Case Report

Nadia Mebrouk, Rachid Abilkassem, Aomar Agadr

Asian Journal of Pediatric Research, Page 9-12
DOI: 10.9734/ajpr/2022/v8i430249

Pycnodysostosis is a rare genetic disease, caused by a mutation of the cathepsin K gene which is involved in bone renewal. It is associated with dwarfism and bone fragility, but the association with a stridor is exceptional. We report the case of a child treated for stridor with sleep apnea syndrome confirmed by sleep recording. His clinical examination showed stridor with laryngomalacia, the characteristic dysmorphism of pycnodysostosis and failure to thrive. The patient was put under non-invasive ventilation during evenings, and underwent ablation of adenoids, which resulted in a stable blood oxygen saturation. A surgery to lengthen the patient’s mandibular is being considered, depending on her evolution. Practitioners should overlook this rare disease when faced with atypical stridor associated with high obstruction, failure to thrive and dysmorphism.

Open Access Original Research Article

Prevalence of Rheumatic Heart Disease among Children in Bangladesh

Santosh Kumar Saha, Kastury Modak, Kazal Kanti Dan, Syed Nasir Uddin, Mohammad Abdullah Al Mamun, Kamrun Nahar Choudhury

Asian Journal of Pediatric Research, Page 1-8
DOI: 10.9734/ajpr/2022/v8i430248

Aims: The prevalence of Rheumatic Heart Disease (RHD) is estimated to be higher in developing countries like Bangladesh than in developed countries, ranging from 24/1,000 to 0.3/1,000 respectively. There is no authentic national data since 2005 on prevalence of RHD in our country. Aim of this study is to find out present status of RHD among children in Bangladesh so that government can take further action to strengthen RHD prevention activity.

Methods: A cross-sectional survey of children aged 5–15 years from 20 schools of urban non slum, urban slum and rural area was carried out by a team of cardiologists. Children were screened by clinical examination and diagnosis confirmed by echocardiography. Children who were not willing to enroll in the study and absent students at the day of data collection were excluded from the study. Ethical permission was taken from the institutional review board.

Results: Total 5024 school children aged 5 to 15 years were screened for rheumatic heart disease. Male female ratio was 1.01. Prevalence of RF and RHD were 1.6/1000 and 0.8/1000 respectively. Prevalence of RHD was significantly higher among urban slum children (3.78/1000) than rural (0.33/1000) and urban non slum children (0.66/1000).

Conclusion: The encouraging observation in our study is a decreasing trend of Rheumatic Fever and Rheumatic Heart Disease in Bangladesh

Open Access Original Research Article

A Clinical Study of 78 Children with Autism

Liu Juan, Hou Lingyun, Meng Xuchun, Cui Zishuo, Bao Yongfei, Wenyan Jiao

Asian Journal of Pediatric Research, Page 19-24
DOI: 10.9734/ajpr/2022/v8i430252

 

Autism, also known as Autism, is a type of pervasive developmental disorder that occurs before the age of 3 and usually manifests in the first or second years of life. The diagnosis of autism falls under one category of mental development disorders. Its incidence is increasing year by year, and there is no specific treatment [1]. This study selected 78 cases of autistic children in Shenmu City Hospital for research and analysis, according to the clinical manifestations, and related laboratory research, examination results, music therapy, comprehensive therapy, intervention methods and their efficacy to analyze and study, suggesting that clinical research on autism should be strengthened.

   

Open Access Original Research Article

Febrile Episodes during Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia at Children Hospital –Benghazi 2013-2014

Salima M. M. Alzehawi, Amina Beayou, Najat B. Elgazal, Fawzia S. Khalifa, Salimah S. Alabeedi, Mohamed M. Alferjani

Asian Journal of Pediatric Research, Page 25-34
DOI: 10.9734/ajpr/2022/v8i430253

Patients undergoing chemotherapy are vulnerable to infection because of immunosuppression and prolonged hospitalizations. Chemotherapy drugs affect neutrophil production through myelosuppression (1) and low inflammatory response so that fever maybe the manifestation of infection (2).

The purpose of this study was to analyze febrile neutropenic episodes associated with infections in the 1st three phases of acute lymphoblastic leukemia (ALL) treatment, document the risk factors affecting morbidity, mortality, treatment and the outcome of treatment.

The study was a cross-sectional hospital-based descriptive survey in the Hematology-Oncology Unit at Children’s Hospital. It included all cases of (ALL) who were diagnosed within two years and treated with the Berlin Frankfurt Munich (BFM) protocol who developed fever during a neutropenic period. Data was recorded as gender, age, residence, nationality, number of episodes per patient, treatment phase, admission duration, length of stay (LOS) per episode, symptoms, physical examination and severity of fever. Investigations, the antibiotic used and the outcome were also recorded.

A total 27children, males accounting for 63%, 67<5 were included in the study. Febrile neutropenic episodes ranged 1–12. Their peak was in January. 40% were in phase II. LOS range 2-35 days. Fever showed a median of 38.8 °C, higher in phase II and III. Admission and therapy phases were longer in children ˂ 2 years old and in males. The neutrophil median was 270/mm3. Stomatitis was seen in70% of episodes, gastroenteritis in 65%, fever of unknown origin (FUO) in 16%and pneumonias in 15%. 20/23 bacterial infections were Gram-negative. 40% of episodes required a change of antibiotics. The mortality rate was 22%.

Open Access Review Article

Updated Research on Autism

Liu Juan, Hou Lingyun, Meng Xuchun, Cui Zishuo, Bao Yongfei, Wenyan Jiao

Asian Journal of Pediatric Research, Page 13-18
DOI: 10.9734/ajpr/2022/v8i430251

Autism begins in childhood, and at its core is a serious interpersonal relationship and communication disorder. The effects of the disorder intervene in multiple ways in relationships with the environment, participation in community life, the ability to adapt to society, and cognitive and language, motor, emotional and interactive functions are all affected. Such individuals perform better in a low-stimulation environment. So finding or creating a friendly environment for people with autism is a fundamental goal. Research on autism is still in its infancy in China, suggesting that clinical research on autism should be strengthened.