Macrophagic Activation Syndrome Revealing Hodgkin Lymphoma: Case Report
Nadia Mebrouk *
Children's Hospital, Rabat, Morocco.
Rachid Abilkassem
Department of Pediatrics, Military Teaching Hospital Mohammed V, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
Anass Ayad
Department of Pediatrics, Military Teaching Hospital Mohammed V, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
Aomar Agadr
Department of Pediatrics, Military Teaching Hospital Mohammed V, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Macrophage Activation Syndrome (MAS), or Haemophagocytosis Syndrome, is a clinical-biological entity characterized by the proliferation and non-specific activation of macrophages of the reticulo-histiocytic system, with phagocytosis of the blood elements formed. This syndrome can be primary in children or secondary to various conditions at any age. Its association with Hodgkin's lymphoma is exceptional. We report here a case of MAS that revealed Hodgkin's lymphoma in a 5-year-old child. And we underline the interest of an urgent diagnosis and a fast care because risk of evolution towards a fatal multivisceral failure.
Keywords: Macrophage activation syndrome, MAS, hemophagocytosis syndrome, Hodgkin's lymphoma